We'll start by breaking down the "A" section melody. I see this as being the "main" melody of Up & Up.
This melody is in Em and is mainly based around an Em7 arpeggio and Em pentatonic.
Other than notes directly from an Em7 arp or the Em pentatonic we'll land on the 13 a couple of times throughout the melody.
Nothing too "out there" at first, but as we continue into the rest of the melody we'll run into some interesting note choices.